Fields »
ABOUT
HELP
BLOG
FUCA2

GENERAL INFORMATION

Gene name

 FUCA2

Gene description

 Fucosidase, alpha-L- 2, plasma

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, most abundant in glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA031659 , HPA031660 , HPA031661
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FUCA2 (HGNC Symbol)

Synonyms

 dJ20N2.5, MGC1314

Description

 Fucosidase, alpha-L- 2, plasma (HGNC Symbol)

Entrez gene summary

 This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

Chromosome

 6

Cytoband

 q24.2

Chromosome location (bp)

 143494811 - 143511690

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000001036 (version 83.38)

Entrez gene

 2519

UniProt

 Q9BTY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTY2

Antibodypedia

 FUCA2 antibodies

PROTEIN BROWSER
FUCA2-001
FUCA2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FUCA2-001
ENSP00000002165
ENST00000002165
Q9BTY2 [Direct mapping]
Plasma alpha-L-fucosidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004560 [alpha-L-fucosidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005975 [carbohydrate metabolic process]
GO:0006004 [fucose metabolic process]
GO:0009617 [response to bacterium]
GO:0016139 [glycoside catabolic process]
GO:0070062 [extracellular exosome]
GO:2000535 [regulation of entry of bacterium into host cell]
Show all
 467 aa
54.1 kDa 		Yes 0
FUCA2-003
ENSP00000398119
ENST00000451668
Q7Z6V2 [Direct mapping]
Plasma alpha-L-fucosidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004560 [alpha-L-fucosidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 109 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.