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NFYA

GENERAL INFORMATION

Gene name

 NFYA

Gene description

 Nuclear transcription factor Y, alpha

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression, high in leukocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA050779 , CAB009250
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA050779
CAB009250

GENE INFORMATION

Gene name

 NFYA (HGNC Symbol)

Synonyms

 CBF-B, HAP2, NF-YA

Description

 Nuclear transcription factor Y, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 41072945 - 41099976

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000001167 (version 83.38)

Entrez gene

 4800

UniProt

 P23511 (UniProt - Evidence at protein level)

neXtProt

 NX_P23511

Antibodypedia

 NFYA antibodies

PROTEIN BROWSER
NFYA-001
NFYA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFYA-001
ENSP00000345702
ENST00000341376
P23511 [Direct mapping]
Nuclear transcription factor Y subunit alpha
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001221 [transcription cofactor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:2000036 [regulation of stem cell population maintenance]
GO:2000648 [positive regulation of stem cell proliferation]
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 347 aa
36.9 kDa 		No 0
NFYA-002
ENSP00000229418
ENST00000353205
P23511 [Direct mapping]
Nuclear transcription factor Y subunit alpha
A0A024RD22 [Target identity:100%; Query identity:100%]
Nuclear transcription factor Y, alpha, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
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 318 aa
33.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.