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Nuclear transcription factor Y, alpha (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
P23511 [Direct mapping] Nuclear transcription factor Y subunit alpha
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Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001046 [core promoter sequence-specific DNA binding] GO:0001221 [transcription cofactor binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0016602 [CCAAT-binding factor complex] GO:0032993 [protein-DNA complex] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation]
Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0016602 [CCAAT-binding factor complex] GO:0032993 [protein-DNA complex] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048511 [rhythmic process]
