Expression of CYP51A1 in cancer - Summary - The Human Protein Atlas

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CYP51A1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYP51A1
Gene description	Cytochrome P450, family 51, subfamily A, polypeptide 1
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in Leydig cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 2 antibodies. HPA041325 , HPA043508
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041325	HPA043508

GENE INFORMATION
Gene name	CYP51A1 (HGNC Symbol)
Synonyms	CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Description	Cytochrome P450, family 51, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	7
Cytoband	q21.2
Chromosome location (bp)	92112151 - 92142952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000001630 (version 83.38)
Entrez gene	1595
UniProt	Q16850 (UniProt - Evidence at protein level)
neXtProt	NX_Q16850
Antibodypedia	CYP51A1 antibodies

PROTEIN BROWSER

CYP51A1-001	CYP51A1-002	CYP51A1-005	CYP51A1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP51A1-001 ENSP00000003100 ENST00000003100	A0A0C4DFL7 [Direct mapping] Lanosterol 14-alpha demethylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0008398 [sterol 14-demethylase activity] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0033488 [cholesterol biosynthetic process via 24,25-dihydrolanosterol] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	509 aa 57.3 kDa	Yes	1
CYP51A1-002 ENSP00000406757 ENST00000450723	Q16850 [Direct mapping] Lanosterol 14-alpha demethylase Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008398 [sterol 14-demethylase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070988 [demethylation] Show all	404 aa 46.3 kDa	No	0
CYP51A1-005 ENSP00000412536 ENST00000435873	C9IYR8 [Direct mapping] Lanosterol 14-alpha demethylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.4 kDa	No	0
CYP51A1-006 ENSP00000394268 ENST00000422867	H7C0D0 [Direct mapping] Lanosterol 14-alpha demethylase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	222 aa 25.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.