Expression of LAP3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LAP3
Gene description	Leucine aminopeptidase 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in essentially all tissues, except for brain and muscle tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA029606 , HPA029607
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029606	HPA029607

GENE INFORMATION
Gene name	LAP3 (HGNC Symbol)
Synonyms	LAP, LAPEP, PEPS
Description	Leucine aminopeptidase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p15.32
Chromosome location (bp)	17577192 - 17607972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002549 (version 83.38)
Entrez gene	51056
UniProt	P28838 (UniProt - Evidence at protein level)
neXtProt	NX_P28838
Antibodypedia	LAP3 antibodies

PROTEIN BROWSER

LAP3-001	LAP3-009	LAP3-010	LAP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAP3-001 ENSP00000226299 ENST00000226299	P28838 [Direct mapping] Cytosol aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005802 [trans-Golgi network] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] GO:0070062 [extracellular exosome] Show all	519 aa 56.2 kDa	No	0
LAP3-009 ENSP00000424724 ENST00000513105	H0Y9Q1 [Direct mapping] Cytosol aminopeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] Show all	209 aa 22.6 kDa	No	0
LAP3-010 ENSP00000476028 ENST00000606142	P28838 [Direct mapping] Cytosol aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] GO:0070062 [extracellular exosome] Show all	488 aa 52.8 kDa	No	0
LAP3-201 ENSP00000481000 ENST00000618908	P28838 [Direct mapping] Cytosol aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] GO:0070062 [extracellular exosome] Show all	519 aa 56.2 kDa	No	0