Expression of CD99 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD99
Gene description	CD99 molecule
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression most abundant in islets of Langerhans, cells in seminiferous ducts and subsets of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA035304 , CAB000020
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035304	CAB000020

GENE INFORMATION
Gene name	CD99 (HGNC Symbol)
Synonyms	MIC2
Description	CD99 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	2691179 - 2741309
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002586 (version 83.38)
Entrez gene	4267
UniProt	P14209 (UniProt - Evidence at protein level)
neXtProt	NX_P14209
Antibodypedia	CD99 antibodies

PROTEIN BROWSER

CD99-001	CD99-002	CD99-003	CD99-004	CD99-005	CD99-010	CD99-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD99-001 ENSP00000370588 ENST00000381192	P14209 [Direct mapping] CD99 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	185 aa 18.8 kDa	Yes	1
CD99-002 ENSP00000370573 ENST00000381180	A6NJT9 [Direct mapping] CD99 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8 kDa	Yes	0
CD99-003 ENSP00000370582 ENST00000381187	P14209 [Direct mapping] CD99 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	169 aa 17.1 kDa	Yes	1
CD99-004 ENSP00000370579 ENST00000381184	A8MQT7 [Direct mapping] CD99 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	177 aa 17.7 kDa	Yes	1
CD99-005 ENSP00000405544 ENST00000449611	H7C2F2 [Direct mapping] CD99 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	201 aa 20.6 kDa	No	1
CD99-010 ENSP00000485427 ENST00000624481	A0A096LP69 [Direct mapping] CD99 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	184 aa 18.8 kDa	Yes	1
CD99-201 ENSP00000479999 ENST00000611428	P14209 [Direct mapping] CD99 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	160 aa 16 kDa	Yes	1