Cell atlas - HECW1 - The Human Protein Atlas

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HECW1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	HECW1
Gene description	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (U-266/70, A549)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA007203
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007203	A549	Cytosol

GENE INFORMATION
Gene name	HECW1 (HGNC Symbol)
Synonyms	KIAA0322, NEDL1
Description	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband
Chromosome location (bp)	43112599 - 43566001
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002746 (version 83.38)
Entrez gene	23072
UniProt	Q76N89 (UniProt - Evidence at protein level)
neXtProt	NX_Q76N89
Antibodypedia	HECW1 antibodies

PROTEIN BROWSER

HECW1-001	HECW1-002	HECW1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HECW1-001 ENSP00000379228 ENST00000395891	Q76N89 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	1606 aa 179.6 kDa	No	0
HECW1-002 ENSP00000407774 ENST00000453890	Q76N89 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	1572 aa 175.7 kDa	No	0
HECW1-007 ENSP00000413336 ENST00000429529	H7C3Q2 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	139 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.