Expression of HECW1 in cancer - Summary - The Human Protein Atlas

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HECW1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HECW1
Gene description	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (A549, U-266/70)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA007593 , HPA007609
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007593	HPA007609

GENE INFORMATION
Gene name	HECW1 (HGNC Symbol)
Synonyms	KIAA0322, NEDL1
Description	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband
Chromosome location (bp)	43112599 - 43566001
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002746 (version 83.38)
Entrez gene	23072
UniProt	Q76N89 (UniProt - Evidence at protein level)
neXtProt	NX_Q76N89
Antibodypedia	HECW1 antibodies

PROTEIN BROWSER

HECW1-001	HECW1-002	HECW1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HECW1-001 ENSP00000379228 ENST00000395891	Q76N89 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	1606 aa 179.6 kDa	No	0
HECW1-002 ENSP00000407774 ENST00000453890	Q76N89 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	1572 aa 175.7 kDa	No	0
HECW1-007 ENSP00000413336 ENST00000429529	H7C3Q2 [Direct mapping] E3 ubiquitin-protein ligase HECW1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	139 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.