Expression of AK2 in cancer - Summary - The Human Protein Atlas

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AK2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AK2
Gene description	Adenylate kinase 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA018479
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Breast cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018479

GENE INFORMATION
Gene name	AK2
Synonyms
Description	Adenylate kinase 2 (HGNC Symbol)
Entrez gene summary	Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]
Chromosome	1
Cytoband	p35.1
Chromosome location (bp)	33007940 - 33080996
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004455 (version 83.38)
Entrez gene	204
UniProt	P54819 (UniProt - Evidence at protein level)
neXtProt	NX_P54819
Antibodypedia	AK2 antibodies

PROTEIN BROWSER

AK2-001	AK2-002	AK2-003	AK2-007	AK2-009	AK2-010	AK2-201	AK2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AK2-001 ENSP00000346921 ENST00000354858	P54819 [Direct mapping] Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial, N-terminally processed Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0004017 [adenylate kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005829 [cytosol] GO:0006119 [oxidative phosphorylation] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006172 [ADP biosynthetic process] GO:0007420 [brain development] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016776 [phosphotransferase activity, phosphate group as acceptor] GO:0019205 [nucleobase-containing compound kinase activity] GO:0036126 [sperm flagellum] GO:0044281 [small molecule metabolic process] GO:0046033 [AMP metabolic process] GO:0046034 [ATP metabolic process] GO:0046060 [dATP metabolic process] GO:0046939 [nucleotide phosphorylation] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0097066 [response to thyroid hormone] GO:0097226 [sperm mitochondrial sheath] Show all	239 aa 26.5 kDa	No	0
AK2-002 ENSP00000362548 ENST00000373449	P54819 [Direct mapping] Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial, N-terminally processed Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004017 [adenylate kinase activity] GO:0005524 [ATP binding] GO:0005758 [mitochondrial intermembrane space] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006172 [ADP biosynthetic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016776 [phosphotransferase activity, phosphate group as acceptor] GO:0019205 [nucleobase-containing compound kinase activity] GO:0044281 [small molecule metabolic process] GO:0046033 [AMP metabolic process] GO:0046034 [ATP metabolic process] GO:0046939 [nucleotide phosphorylation] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	232 aa 25.6 kDa	No	0
AK2-003 ENSP00000447082 ENST00000467905	F8W1A4 [Direct mapping] Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004017 [adenylate kinase activity] GO:0005524 [ATP binding] GO:0005758 [mitochondrial intermembrane space] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006172 [ADP biosynthetic process] GO:0016776 [phosphotransferase activity, phosphate group as acceptor] GO:0019205 [nucleobase-containing compound kinase activity] GO:0046033 [AMP metabolic process] GO:0046034 [ATP metabolic process] GO:0046939 [nucleotide phosphorylation] Show all	232 aa 25.6 kDa	No	0
AK2-007 ENSP00000446849 ENST00000487289	F8VZG5 [Direct mapping] Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0016310 [phosphorylation] GO:0019205 [nucleobase-containing compound kinase activity] Show all	162 aa 17.5 kDa	No	0
AK2-009 ENSP00000450109 ENST00000480134	G3V213 [Direct mapping] Adenylate kinase 2, isoform CRA_a; Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0016310 [phosphorylation] GO:0019205 [nucleobase-containing compound kinase activity] Show all	133 aa 14.3 kDa	No	0
AK2-010 ENSP00000449003 ENST00000548033	F8VY04 [Direct mapping] Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004017 [adenylate kinase activity] GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0019205 [nucleobase-containing compound kinase activity] GO:0046939 [nucleotide phosphorylation] Show all	190 aa 21.2 kDa	No	0
AK2-201 ENSP00000486342 ENST00000626911	F8VPP1 [Direct mapping] Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.5 kDa	No	0
AK2-202 ENSP00000486507 ENST00000629371	G3V213 [Direct mapping] Adenylate kinase 2, isoform CRA_a; Adenylate kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0016310 [phosphorylation] GO:0019205 [nucleobase-containing compound kinase activity] Show all	133 aa 14.3 kDa	No	0

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