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AK2

GENERAL INFORMATION

Gene name

 AK2

Gene description

 Adenylate kinase 2

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018479
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AK2

Synonyms

Description

 Adenylate kinase 2 (HGNC Symbol)

Entrez gene summary

 Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Chromosome

 1

Cytoband

 p35.1

Chromosome location (bp)

 33007940 - 33080996

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004455 (version 83.38)

Entrez gene

 204

UniProt

 P54819 (UniProt - Evidence at protein level)

neXtProt

 NX_P54819

Antibodypedia

 AK2 antibodies

PROTEIN BROWSER
AK2-001
AK2-002
AK2-003
AK2-007
AK2-009
AK2-010
AK2-201
AK2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK2-001
ENSP00000346921
ENST00000354858
P54819 [Direct mapping]
Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial, N-terminally processed
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004017 [adenylate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006119 [oxidative phosphorylation]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007420 [brain development]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0036126 [sperm flagellum]
GO:0044281 [small molecule metabolic process]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046060 [dATP metabolic process]
GO:0046939 [nucleotide phosphorylation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0097066 [response to thyroid hormone]
GO:0097226 [sperm mitochondrial sheath]
Show all
 239 aa
26.5 kDa 		No 0
AK2-002
ENSP00000362548
ENST00000373449
P54819 [Direct mapping]
Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005524 [ATP binding]
GO:0005758 [mitochondrial intermembrane space]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046939 [nucleotide phosphorylation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 232 aa
25.6 kDa 		No 0
AK2-003
ENSP00000447082
ENST00000467905
F8W1A4 [Direct mapping]
Adenylate kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005524 [ATP binding]
GO:0005758 [mitochondrial intermembrane space]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046939 [nucleotide phosphorylation]
Show all
 232 aa
25.6 kDa 		No 0
AK2-007
ENSP00000446849
ENST00000487289
F8VZG5 [Direct mapping]
Adenylate kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 162 aa
17.5 kDa 		No 0
AK2-009
ENSP00000450109
ENST00000480134
G3V213 [Direct mapping]
Adenylate kinase 2, isoform CRA_a; Adenylate kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 133 aa
14.3 kDa 		No 0
AK2-010
ENSP00000449003
ENST00000548033
F8VY04 [Direct mapping]
Adenylate kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046939 [nucleotide phosphorylation]
Show all
 190 aa
21.2 kDa 		No 0
AK2-201
ENSP00000486342
ENST00000626911
F8VPP1 [Direct mapping]
Adenylate kinase 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
4.5 kDa 		No 0
AK2-202
ENSP00000486507
ENST00000629371
G3V213 [Direct mapping]
Adenylate kinase 2, isoform CRA_a; Adenylate kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 133 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.