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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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KDM1A
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

KDM1A

Gene description

Lysine (K)-specific demethylase 1A

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB005884
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

CAB005884

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong nuclear immunoreactivity was observed in malignant lymphomas and a few cases of gliomas, renal cancers and breast cancers. Most other tumors were negative.

GENE INFORMATION

Gene name

KDM1A (HGNC Symbol)

Synonyms

AOF2, BHC110, KDM1, KIAA0601, LSD1

Description

Lysine (K)-specific demethylase 1A (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

23019448 - 23083689

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000004487 (version 83.38)

Entrez gene

23028

UniProt

O60341 (UniProt - Evidence at protein level)

neXtProt

NX_O60341

Antibodypedia

KDM1A antibodies

PROTEIN BROWSER

KDM1A-001
KDM1A-002
KDM1A-004
KDM1A-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDM1A-001
ENSP00000349049
ENST00000356634
O60341 [Direct mapping]
Lysine-specific histone demethylase 1A
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006482 [protein demethylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016491 [oxidoreductase activity]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0032091 [negative regulation of protein binding]
GO:0032451 [demethylase activity]
GO:0032452 [histone demethylase activity]
GO:0032453 [histone demethylase activity (H3-K4 specific)]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0033184 [positive regulation of histone ubiquitination]
GO:0034644 [cellular response to UV]
GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)]
GO:0034720 [histone H3-K4 demethylation]
GO:0043234 [protein complex]
GO:0043392 [negative regulation of DNA binding]
GO:0043426 [MRF binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0055001 [muscle cell development]
GO:0055114 [oxidation-reduction process]
GO:0071480 [cellular response to gamma radiation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:1903827 [regulation of cellular protein localization]
GO:1990391 [DNA repair complex]
Show all
852 aa
92.9 kDa
Yes 0
KDM1A-002
ENSP00000383042
ENST00000400181
O60341 [Direct mapping]
Lysine-specific histone demethylase 1A
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001701 [in utero embryonic development]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006482 [protein demethylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010725 [regulation of primitive erythrocyte differentiation]
GO:0016491 [oxidoreductase activity]
GO:0019899 [enzyme binding]
GO:0021983 [pituitary gland development]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030851 [granulocyte differentiation]
GO:0032091 [negative regulation of protein binding]
GO:0032451 [demethylase activity]
GO:0032452 [histone demethylase activity]
GO:0032453 [histone demethylase activity (H3-K4 specific)]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0033184 [positive regulation of histone ubiquitination]
GO:0034644 [cellular response to UV]
GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)]
GO:0034720 [histone H3-K4 demethylation]
GO:0043234 [protein complex]
GO:0043392 [negative regulation of DNA binding]
GO:0043426 [MRF binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045654 [positive regulation of megakaryocyte differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046886 [positive regulation of hormone biosynthetic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0055001 [muscle cell development]
GO:0055114 [oxidation-reduction process]
GO:0071480 [cellular response to gamma radiation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:1903827 [regulation of cellular protein localization]
GO:1990391 [DNA repair complex]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000648 [positive regulation of stem cell proliferation]
Show all
876 aa
95.2 kDa
Yes 0
KDM1A-004
ENSP00000473294
ENST00000494920
R4GMP9 [Direct mapping]
Lysine-specific histone demethylase 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
302 aa
32.5 kDa
No 0
KDM1A-005
ENSP00000473297
ENST00000465864
R4GMQ1 [Direct mapping]
Lysine-specific histone demethylase 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
189 aa
21.3 kDa
No 0

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