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Moderate to strong nuclear immunoreactivity was observed in malignant lymphomas and a few cases of gliomas, renal cancers and breast cancers. Most other tumors were negative.
GENE INFORMATION
Gene name
KDM1A (HGNC Symbol)
Synonyms
AOF2, BHC110, KDM1, KIAA0601, LSD1
Description
Lysine (K)-specific demethylase 1A (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006482 [protein demethylation] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0016491 [oxidoreductase activity] GO:0019899 [enzyme binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0032091 [negative regulation of protein binding] GO:0032451 [demethylase activity] GO:0032452 [histone demethylase activity] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0032454 [histone demethylase activity (H3-K9 specific)] GO:0033169 [histone H3-K9 demethylation] GO:0033184 [positive regulation of histone ubiquitination] GO:0034644 [cellular response to UV] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0043234 [protein complex] GO:0043392 [negative regulation of DNA binding] GO:0043426 [MRF binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050660 [flavin adenine dinucleotide binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0055001 [muscle cell development] GO:0055114 [oxidation-reduction process] GO:0071480 [cellular response to gamma radiation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1903827 [regulation of cellular protein localization] GO:1990391 [DNA repair complex]
SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001701 [in utero embryonic development] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006482 [protein demethylation] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010725 [regulation of primitive erythrocyte differentiation] GO:0016491 [oxidoreductase activity] GO:0019899 [enzyme binding] GO:0021983 [pituitary gland development] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030851 [granulocyte differentiation] GO:0032091 [negative regulation of protein binding] GO:0032451 [demethylase activity] GO:0032452 [histone demethylase activity] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0032454 [histone demethylase activity (H3-K9 specific)] GO:0033169 [histone H3-K9 demethylation] GO:0033184 [positive regulation of histone ubiquitination] GO:0034644 [cellular response to UV] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0043234 [protein complex] GO:0043392 [negative regulation of DNA binding] GO:0043426 [MRF binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044212 [transcription regulatory region DNA binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045654 [positive regulation of megakaryocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046886 [positive regulation of hormone biosynthetic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0055001 [muscle cell development] GO:0055114 [oxidation-reduction process] GO:0071480 [cellular response to gamma radiation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1903827 [regulation of cellular protein localization] GO:1990391 [DNA repair complex] GO:2000179 [positive regulation of neural precursor cell proliferation] GO:2000648 [positive regulation of stem cell proliferation]