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PDK4

GENERAL INFORMATION

Gene name

 PDK4

Gene description

 Pyruvate dehydrogenase kinase, isozyme 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, HeLa, RPTEC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA056731
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056731

GENE INFORMATION

Gene name

 PDK4

Synonyms

Description

 Pyruvate dehydrogenase kinase, isozyme 4 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 95583499 - 95596491

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004799 (version 83.38)

Entrez gene

 5166

UniProt

 Q16654 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16654

Antibodypedia

 PDK4 antibodies

PROTEIN BROWSER
PDK4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDK4-001
ENSP00000005178
ENST00000005178
Q16654 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
A4D1H4 [Target identity:100%; Query identity:100%]
Pyruvate dehydrogenase kinase, isoenzyme 4; Pyruvate dehydrogenase kinase, isozyme 4, isoform CRA_a; cDNA, FLJ92766, Homo sapiens pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4), mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006885 [regulation of pH]
GO:0008286 [insulin receptor signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010565 [regulation of cellular ketone metabolic process]
GO:0010906 [regulation of glucose metabolic process]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0042594 [response to starvation]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045124 [regulation of bone resorption]
GO:0046320 [regulation of fatty acid oxidation]
GO:0071398 [cellular response to fatty acid]
GO:0072593 [reactive oxygen species metabolic process]
GO:2000811 [negative regulation of anoikis]
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 411 aa
46.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.