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This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Atypical kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0004672 [protein kinase activity] GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006468 [protein phosphorylation] GO:0006885 [regulation of pH] GO:0008286 [insulin receptor signaling pathway] GO:0009267 [cellular response to starvation] GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] GO:0010565 [regulation of cellular ketone metabolic process] GO:0010906 [regulation of glucose metabolic process] GO:0042304 [regulation of fatty acid biosynthetic process] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045124 [regulation of bone resorption] GO:0046320 [regulation of fatty acid oxidation] GO:0071398 [cellular response to fatty acid] GO:0072593 [reactive oxygen species metabolic process] GO:2000811 [negative regulation of anoikis]
