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SLC22A16

GENERAL INFORMATION

Gene name

 SLC22A16

Gene description

 Solute carrier family 22 (organic cation/carnitine transporter), member 16

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (endometrial cancer)
HPA (cell line):Group enriched (NB-4, REH, THP-1, U-937)
HPA (normal tissue):Group enriched (bone marrow, parathyroid gland, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA036902
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036902

GENE INFORMATION

Gene name

 SLC22A16 (HGNC Symbol)

Synonyms

 CT2, FLIPT2, OAT6, OKB1

Description

 Solute carrier family 22 (organic cation/carnitine transporter), member 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 110424687 - 110476641

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004809 (version 83.38)

Entrez gene

 85413

UniProt

 Q86VW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86VW1

Antibodypedia

 SLC22A16 antibodies

PROTEIN BROWSER
SLC22A16-001
SLC22A16-002
SLC22A16-004
SLC22A16-005
SLC22A16-006
SLC22A16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A16-001
ENSP00000357915
ENST00000368919
Q86VW1 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005275 [amine transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015226 [carnitine transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015837 [amine transport]
GO:0015879 [carnitine transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030154 [cell differentiation]
GO:0030317 [sperm motility]
GO:0046717 [acid secretion]
GO:0055085 [transmembrane transport]
GO:1902603 [carnitine transmembrane transport]
Show all
 577 aa
64.6 kDa 		No >9
SLC22A16-002
ENSP00000395642
ENST00000451557
X6RE50 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 432 aa
48.7 kDa 		No >9
SLC22A16-004
ENSP00000409306
ENST00000434949
C9JTF8 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 267 aa
30 kDa 		No 7
SLC22A16-005
ENSP00000416310
ENST00000437378
C9JGT0 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 351 aa
40.1 kDa 		No 7
SLC22A16-006
ENSP00000401007
ENST00000424139
C9JU94 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 174 aa
19.8 kDa 		No 2
SLC22A16-201
ENSP00000328583
ENST00000330550
Q86VW1 [Direct mapping]
Solute carrier family 22 member 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005275 [amine transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015226 [carnitine transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015837 [amine transport]
GO:0015879 [carnitine transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030154 [cell differentiation]
GO:0030317 [sperm motility]
GO:0046717 [acid secretion]
GO:0055085 [transmembrane transport]
GO:1902603 [carnitine transmembrane transport]
Show all
 543 aa
60.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.