Tissue expression of SLC22A16 - Summary - The Human Protein Atlas

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SLC22A16

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC22A16
Gene description	Solute carrier family 22 (organic cation/carnitine transporter), member 16
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (bone marrow, parathyroid gland, testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA036902
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (bone marrow, parathyroid gland, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	SLC22A16 (HGNC Symbol)
Synonyms	CT2, FLIPT2, OAT6, OKB1
Description	Solute carrier family 22 (organic cation/carnitine transporter), member 16 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	110424687 - 110476641
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004809 (version 83.38)
Entrez gene	85413
UniProt	Q86VW1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VW1
Antibodypedia	SLC22A16 antibodies

PROTEIN BROWSER

SLC22A16-001	SLC22A16-002	SLC22A16-004	SLC22A16-005	SLC22A16-006	SLC22A16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A16-001 ENSP00000357915 ENST00000368919	Q86VW1 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005275 [amine transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0015101 [organic cation transmembrane transporter activity] GO:0015226 [carnitine transmembrane transporter activity] GO:0015695 [organic cation transport] GO:0015837 [amine transport] GO:0015879 [carnitine transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0030317 [sperm motility] GO:0046717 [acid secretion] GO:0055085 [transmembrane transport] GO:1902603 [carnitine transmembrane transport] Show all	577 aa 64.6 kDa	No	>9
SLC22A16-002 ENSP00000395642 ENST00000451557	X6RE50 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	432 aa 48.7 kDa	No	>9
SLC22A16-004 ENSP00000409306 ENST00000434949	C9JTF8 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	267 aa 30 kDa	No	7
SLC22A16-005 ENSP00000416310 ENST00000437378	C9JGT0 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	351 aa 40.1 kDa	No	7
SLC22A16-006 ENSP00000401007 ENST00000424139	C9JU94 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	174 aa 19.8 kDa	No	2
SLC22A16-201 ENSP00000328583 ENST00000330550	Q86VW1 [Direct mapping] Solute carrier family 22 member 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005275 [amine transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0015101 [organic cation transmembrane transporter activity] GO:0015226 [carnitine transmembrane transporter activity] GO:0015695 [organic cation transport] GO:0015837 [amine transport] GO:0015879 [carnitine transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0030317 [sperm motility] GO:0046717 [acid secretion] GO:0055085 [transmembrane transport] GO:1902603 [carnitine transmembrane transport] Show all	543 aa 60.9 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.