Expression of ZMYND10 in cancer - Summary - The Human Protein Atlas

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ZMYND10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZMYND10
Gene description	Zinc finger, MYND-type containing 10
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enhanced (T-47d, U-87 MG)
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035255
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035255

GENE INFORMATION
Gene name	ZMYND10 (HGNC Symbol)
Synonyms	BLU, CILD22
Description	Zinc finger, MYND-type containing 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	50341110 - 50346852
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004838 (version 83.38)
Entrez gene	51364
UniProt	O75800 (UniProt - Evidence at protein level)
neXtProt	NX_O75800
Antibodypedia	ZMYND10 antibodies

PROTEIN BROWSER

ZMYND10-001	ZMYND10-002	ZMYND10-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZMYND10-001 ENSP00000231749 ENST00000231749	O75800 [Direct mapping] Zinc finger MYND domain-containing protein 10 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0034451 [centriolar satellite] GO:0036158 [outer dynein arm assembly] GO:0036159 [inner dynein arm assembly] GO:0044458 [motile cilium assembly] GO:0046872 [metal ion binding] Show all	440 aa 50.3 kDa	No	0
ZMYND10-002 ENSP00000353289 ENST00000360165	O75800 [Direct mapping] Zinc finger MYND domain-containing protein 10 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0034451 [centriolar satellite] GO:0036158 [outer dynein arm assembly] GO:0036159 [inner dynein arm assembly] GO:0044458 [motile cilium assembly] GO:0046872 [metal ion binding] Show all	435 aa 50 kDa	No	0
ZMYND10-003 ENSP00000393687 ENST00000442887	C9JUQ8 [Direct mapping] Zinc finger MYND domain-containing protein 10 Show all	Predicted intracellular proteins Show all		282 aa 31.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.