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ABCB5

GENERAL INFORMATION

Gene name

 ABCB5

Gene description

 ATP-binding cassette, sub-family B (MDR/TAP), member 5

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA026975
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026975

GENE INFORMATION

Gene name

 ABCB5 (HGNC Symbol)

Synonyms

 ABCB5alpha, ABCB5beta, EST422562

Description

 ATP-binding cassette, sub-family B (MDR/TAP), member 5 (HGNC Symbol)

Entrez gene summary

 ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

Chromosome

 7

Cytoband

 p21.1

Chromosome location (bp)

 20615207 - 20777038

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004846 (version 83.38)

Entrez gene

 340273

UniProt

 Q2M3G0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q2M3G0

Antibodypedia

 ABCB5 antibodies

PROTEIN BROWSER
ABCB5-001
ABCB5-002
ABCB5-003
ABCB5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCB5-001
ENSP00000258738
ENST00000258738
Q2M3G0 [Direct mapping]
ATP-binding cassette sub-family B member 5
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0015562 [efflux transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030154 [cell differentiation]
GO:0042391 [regulation of membrane potential]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0048058 [compound eye corneal lens development]
GO:0055085 [transmembrane transport]
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 812 aa
89.8 kDa 		No 5
ABCB5-002
ENSP00000383899
ENST00000406935
Q2M3G0 [Direct mapping]
ATP-binding cassette sub-family B member 5
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Show all
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008152 [metabolic process]
GO:0015562 [efflux transmembrane transporter activity]
GO:0016887 [ATPase activity]
GO:0030154 [cell differentiation]
GO:0042391 [regulation of membrane potential]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0048058 [compound eye corneal lens development]
GO:0055085 [transmembrane transport]
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 126 aa
14.1 kDa 		No 0
ABCB5-003
ENSP00000406730
ENST00000443026
Q2M3G0 [Direct mapping]
ATP-binding cassette sub-family B member 5
A0A024RA03 [Target identity:100%; Query identity:100%]
HCG38926, isoform CRA_a
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Show all
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008152 [metabolic process]
GO:0015562 [efflux transmembrane transporter activity]
GO:0016887 [ATPase activity]
GO:0030154 [cell differentiation]
GO:0042391 [regulation of membrane potential]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0048058 [compound eye corneal lens development]
GO:0055085 [transmembrane transport]
Show all
 131 aa
14.7 kDa 		No 0
ABCB5-004
ENSP00000384881
ENST00000404938
Q2M3G0 [Direct mapping]
ATP-binding cassette sub-family B member 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0015562 [efflux transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030154 [cell differentiation]
GO:0042391 [regulation of membrane potential]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0048058 [compound eye corneal lens development]
GO:0055085 [transmembrane transport]
Show all
 1257 aa
138.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.