Expression of COPZ2 in cancer - Summary - The Human Protein Atlas

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COPZ2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COPZ2
Gene description	Coatomer protein complex, subunit zeta 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ, BJ hTERT+)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA055999
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055999

GENE INFORMATION
Gene name	COPZ2 (HGNC Symbol)
Synonyms	MGC23008
Description	Coatomer protein complex, subunit zeta 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48026167 - 48038030
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005243 (version 83.38)
Entrez gene	51226
UniProt	Q9P299 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P299
Antibodypedia	COPZ2 antibodies

PROTEIN BROWSER

COPZ2-001	COPZ2-002	COPZ2-003	COPZ2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COPZ2-001 ENSP00000480707 ENST00000621465	Q9P299 [Direct mapping] Coatomer subunit zeta-2 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005801 [cis-Golgi network] GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030126 [COPI vesicle coat] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] Show all	210 aa 23.5 kDa	No	0
COPZ2-002 ENSP00000463581 ENST00000580174	A0A0G2JLH9 [Direct mapping] Coatomer subunit zeta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1.2 kDa	No	0
COPZ2-003 ENSP00000462035 ENST00000581756	J3KRJ9 [Direct mapping] Coatomer subunit zeta-2 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0015031 [protein transport] Show all	141 aa 16 kDa	No	0
COPZ2-006 ENSP00000463841 ENST00000579263	J3QQQ5 [Direct mapping] Coatomer subunit zeta-2 Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0015031 [protein transport] Show all	79 aa 9.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.