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ABCB4

GENERAL INFORMATION

Gene name

 ABCB4

Gene description

 ATP-binding cassette, sub-family B (MDR/TAP), member 4

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (SH-SY5Y, WM-115)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression of bile canaliculi in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA049395 , HPA053288
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049395
HPA053288

GENE INFORMATION

Gene name

 ABCB4 (HGNC Symbol)

Synonyms

 ABCB4, GBD1, MDR2, MDR3 , PFIC-3, PGY3

Description

 ATP-binding cassette, sub-family B (MDR/TAP), member 4 (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.12

Chromosome location (bp)

 87401697 - 87480435

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005471 (version 83.38)

Entrez gene

 5244

UniProt

 P21439 (UniProt - Evidence at protein level)

neXtProt

 NX_P21439

Antibodypedia

 ABCB4 antibodies

PROTEIN BROWSER
ABCB4-001
ABCB4-002
ABCB4-003
ABCB4-008
ABCB4-009
ABCB4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCB4-001
ENSP00000352135
ENST00000359206
P21439 [Direct mapping]
Phosphatidylcholine translocator ABCB4
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0030136 [clathrin-coated vesicle]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032782 [bile acid secretion]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042908 [xenobiotic transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061092 [positive regulation of phospholipid translocation]
GO:0070062 [extracellular exosome]
GO:0090554 [phosphatidylcholine-translocating ATPase activity]
GO:1901557 [response to fenofibrate]
GO:1903413 [cellular response to bile acid]
GO:2001140 [positive regulation of phospholipid transport]
Show all
 1279 aa
140.7 kDa 		No >9
ABCB4-002
ENSP00000265723
ENST00000265723
P21439 [Direct mapping]
Phosphatidylcholine translocator ABCB4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0030136 [clathrin-coated vesicle]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032782 [bile acid secretion]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042908 [xenobiotic transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0046581 [intercellular canaliculus]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061092 [positive regulation of phospholipid translocation]
GO:0070062 [extracellular exosome]
GO:0090554 [phosphatidylcholine-translocating ATPase activity]
GO:1901557 [response to fenofibrate]
GO:1903413 [cellular response to bile acid]
GO:2001140 [positive regulation of phospholipid transport]
Show all
 1286 aa
141.5 kDa 		No >9
ABCB4-003
ENSP00000394511
ENST00000417608
E7EQI1 [Direct mapping]
Multidrug resistance protein 3
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Predicted intracellular proteins
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GO:0055085 [transmembrane transport]
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 61 aa
6.9 kDa 		No 0
ABCB4-008
ENSP00000395716
ENST00000440025
H7C0M2 [Direct mapping]
Multidrug resistance protein 3
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Predicted intracellular proteins
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GO:0055085 [transmembrane transport]
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 99 aa
11.1 kDa 		No 0
ABCB4-009
ENSP00000392983
ENST00000453593
P21439 [Direct mapping]
Phosphatidylcholine translocator ABCB4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0030136 [clathrin-coated vesicle]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032782 [bile acid secretion]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042908 [xenobiotic transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061092 [positive regulation of phospholipid translocation]
GO:0070062 [extracellular exosome]
GO:0090554 [phosphatidylcholine-translocating ATPase activity]
GO:1901557 [response to fenofibrate]
GO:1903413 [cellular response to bile acid]
GO:2001140 [positive regulation of phospholipid transport]
Show all
 1232 aa
135.3 kDa 		No >9
ABCB4-201
ENSP00000351172
ENST00000358400
P21439 [Direct mapping]
Phosphatidylcholine translocator ABCB4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0030136 [clathrin-coated vesicle]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032782 [bile acid secretion]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042908 [xenobiotic transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061092 [positive regulation of phospholipid translocation]
GO:0070062 [extracellular exosome]
GO:0090554 [phosphatidylcholine-translocating ATPase activity]
GO:1901557 [response to fenofibrate]
GO:1903413 [cellular response to bile acid]
GO:2001140 [positive regulation of phospholipid transport]
Show all
 1232 aa
135.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.