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KMT2E

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GENERAL INFORMATION

Gene name

 KMT2E

Gene description

 Lysine (K)-specific methyltransferase 2E

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KMT2E (HGNC Symbol)

Synonyms

 HDCMC04P, MLL5

Description

 Lysine (K)-specific methyltransferase 2E (HGNC Symbol)

Entrez gene summary

 This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 105014179 - 105114361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005483 (version 83.38)

Entrez gene

 55904

UniProt

 Q8IZD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZD2

Antibodypedia

 KMT2E antibodies

PROTEIN BROWSER
KMT2E-001
KMT2E-003
KMT2E-007
KMT2E-008
KMT2E-009
KMT2E-012
KMT2E-016
KMT2E-201
KMT2E-202
KMT2E-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KMT2E-001
ENSP00000312379
ENST00000311117
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 1858 aa
205 kDa 		No 0
KMT2E-003
ENSP00000417888
ENST00000476671
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 609 aa
68.9 kDa 		No 1
KMT2E-007
ENSP00000417156
ENST00000473063
H7C4F3 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
13.3 kDa 		No 0
KMT2E-008
ENSP00000420415
ENST00000495267
C9JNE1 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 230 aa
25.4 kDa 		No 0
KMT2E-009
ENSP00000419883
ENST00000478990
C9JYI9 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 352 aa
40.2 kDa 		No 0
KMT2E-012
ENSP00000420206
ENST00000474203
C9JQ68 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
7.7 kDa 		No 0
KMT2E-016
ENSP00000473963
ENST00000479838
S4R363 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
16.3 kDa 		No 0
KMT2E-201
ENSP00000257745
ENST00000257745
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 1858 aa
205 kDa 		No 0
KMT2E-202
ENSP00000333986
ENST00000334914
E7ETZ7 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
Show all
 1778 aa
195.7 kDa 		No 0
KMT2E-203
ENSP00000482147
ENST00000622386
A0A087WYW5 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 453 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.