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KMT2E

GENERAL INFORMATION

Gene name

 KMT2E

Gene description

 Lysine (K)-specific methyltransferase 2E

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA056125
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KMT2E (HGNC Symbol)

Synonyms

 HDCMC04P, MLL5

Description

 Lysine (K)-specific methyltransferase 2E (HGNC Symbol)

Entrez gene summary

 This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 105014179 - 105114361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005483 (version 83.38)

Entrez gene

 55904

UniProt

 Q8IZD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZD2

Antibodypedia

 KMT2E antibodies

PROTEIN BROWSER
KMT2E-001
KMT2E-003
KMT2E-007
KMT2E-008
KMT2E-009
KMT2E-012
KMT2E-016
KMT2E-201
KMT2E-202
KMT2E-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KMT2E-001
ENSP00000312379
ENST00000311117
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 1858 aa
205 kDa 		No 0
KMT2E-003
ENSP00000417888
ENST00000476671
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 609 aa
68.9 kDa 		No 1
KMT2E-007
ENSP00000417156
ENST00000473063
H7C4F3 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
13.3 kDa 		No 0
KMT2E-008
ENSP00000420415
ENST00000495267
C9JNE1 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 230 aa
25.4 kDa 		No 0
KMT2E-009
ENSP00000419883
ENST00000478990
C9JYI9 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 352 aa
40.2 kDa 		No 0
KMT2E-012
ENSP00000420206
ENST00000474203
C9JQ68 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
7.7 kDa 		No 0
KMT2E-016
ENSP00000473963
ENST00000479838
S4R363 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
16.3 kDa 		No 0
KMT2E-201
ENSP00000257745
ENST00000257745
Q8IZD2 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002446 [neutrophil mediated immunity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0042119 [neutrophil activation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051568 [histone H3-K4 methylation]
GO:0070688 [MLL5-L complex]
GO:0071300 [cellular response to retinoic acid]
Show all
 1858 aa
205 kDa 		No 0
KMT2E-202
ENSP00000333986
ENST00000334914
E7ETZ7 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
Show all
 1778 aa
195.7 kDa 		No 0
KMT2E-203
ENSP00000482147
ENST00000622386
A0A087WYW5 [Direct mapping]
Histone-lysine N-methyltransferase 2E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 453 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.