Cell atlas - ITGA2B - The Human Protein Atlas

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ITGA2B

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ITGA2B
Gene description	Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Protein class	Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the cell junctions & nucleoplasm.
RNA cell category	Group enriched (HMC-1, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain), Cell Junctions (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA031171
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the cell junctions & nucleoplasm.

Main location

Cytosol (uncertain)

Additional location

Nucleoplasm (uncertain), Cell Junctions (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031171	A-431	Nucleoplasm
			Cell Junctions
			Cytosol
	HPA031171	U-2 OS	Cytosol
	HPA031171	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ITGA2B (HGNC Symbol)
Synonyms	CD41, CD41B, GP2B, PPP1R93
Description	Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (HGNC Symbol)
Entrez gene summary	ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44372180 - 44389505
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005961 (version 83.38)
Entrez gene	3674
UniProt	P08514 (UniProt - Evidence at protein level)
neXtProt	NX_P08514
Antibodypedia	ITGA2B antibodies

PROTEIN BROWSER

ITGA2B-001	ITGA2B-011	ITGA2B-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGA2B-001 ENSP00000262407 ENST00000262407	P08514 [Direct mapping] Integrin alpha-IIb Integrin alpha-IIb heavy chain Integrin alpha-IIb light chain, form 1 Integrin alpha-IIb light chain, form 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0031092 [platelet alpha granule membrane] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0050840 [extracellular matrix binding] GO:0070051 [fibrinogen binding] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0072562 [blood microparticle] Show all	1039 aa 113.4 kDa	Yes	1
ITGA2B-011 ENSP00000467269 ENST00000587295	K7EP83 [Direct mapping] Integrin alpha-IIb Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.4 kDa	No	0
ITGA2B-012 ENSP00000465534 ENST00000588098	K7EKA6 [Direct mapping] Integrin alpha-IIb Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.