Expression of KRT33A in cancer - Summary - The Human Protein Atlas

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KRT33A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT33A
Gene description	Keratin 33A, type I
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enhanced (RT4)
HPA (normal tissue):	Group enriched (esophagus, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in hair follicle cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA055194
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055194

GENE INFORMATION
Gene name	KRT33A (HGNC Symbol)
Synonyms	Ha-3I, Krt1-3, KRTHA3A
Description	Keratin 33A, type I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41346092 - 41350812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006059 (version 83.38)
Entrez gene	3883
UniProt	O76009 (UniProt - Evidence at transcript level)
neXtProt	NX_O76009
Antibodypedia	KRT33A antibodies

PROTEIN BROWSER

KRT33A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT33A-001 ENSP00000007735 ENST00000007735	O76009 [Direct mapping] Keratin, type I cuticular Ha3-I Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005615 [extracellular space] GO:0005882 [intermediate filament] Show all	404 aa 45.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.