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DLX6

GENERAL INFORMATION

Gene name

 DLX6

Gene description

 Distal-less homeobox 6

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (endometrial cancer)
HPA (cell line):Cell line enhanced (AN3-CA, BEWO, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (endometrium, placenta, testis)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030608
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA030608

GENE INFORMATION

Gene name

 DLX6

Synonyms

Description

 Distal-less homeobox 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 97005548 - 97011039

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000006377 (version 83.38)

Entrez gene

 1750

UniProt

 P56179 (UniProt - Evidence at transcript level)

neXtProt

 NX_P56179

Antibodypedia

 DLX6 antibodies

PROTEIN BROWSER
DLX6-001
DLX6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLX6-001
ENSP00000428480
ENST00000518156
P56179 [Direct mapping]
Homeobox protein DLX-6
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030855 [epithelial cell differentiation]
GO:0042472 [inner ear morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060021 [palate development]
GO:0060322 [head development]
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 293 aa
32.6 kDa 		No 0
DLX6-003
ENSP00000451635
ENST00000555308
G3V471 [Direct mapping]
Homeobox protein DLX-6
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 165 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.