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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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RALA
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

RALA

Gene description

V-ral simian leukemia viral oncogene homolog A (ras related)

Protein class

Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 1 antibody.
HPA065232
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA065232

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic immunoreactivity with additional membranous staining in several cases was observed in cancer tissues.

GENE INFORMATION

Gene name

RALA (HGNC Symbol)

Synonyms

RAL

Description

V-ral simian leukemia viral oncogene homolog A (ras related) (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p14.1

Chromosome location (bp)

39623483 - 39708124

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000006451 (version 83.38)

Entrez gene

5898

UniProt

P11233 (UniProt - Evidence at protein level)

neXtProt

NX_P11233

Antibodypedia

RALA antibodies

PROTEIN BROWSER

RALA-001
RALA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RALA-001
ENSP00000005257
ENST00000005257
P11233 [Direct mapping]
Ras-related protein Ral-A
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001843 [neural tube closure]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0009986 [cell surface]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017022 [myosin binding]
GO:0017157 [regulation of exocytosis]
GO:0019003 [GDP binding]
GO:0030139 [endocytic vesicle]
GO:0030496 [midbody]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031755 [Edg-2 lysophosphatidic acid receptor binding]
GO:0032154 [cleavage furrow]
GO:0043209 [myelin sheath]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051665 [membrane raft localization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
206 aa
23.6 kDa
No 0
RALA-003
ENSP00000388975
ENST00000436179
C9JPE8 [Direct mapping]
Ras-related protein Ral-A
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
101 aa
11.2 kDa
No 0

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