Cell atlas - AGK - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AGK

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Vesicles

Human cell
	Mitochondria
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	AGK
Gene description	Acylglycerol kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA053471
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to vesicles.

Main location

Mitochondria (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053471	HEK 293	Vesicles
	HPA053471	HEK 293	Mitochondria
	HPA053471	U-2 OS	Vesicles
	HPA053471	U-2 OS	Mitochondria
	HPA053471	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	AGK (HGNC Symbol)
Synonyms	FLJ10842, MULK
Description	Acylglycerol kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	141551189 - 141655244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006530 (version 83.38)
Entrez gene	55750
UniProt	Q53H12 (UniProt - Evidence at protein level)
neXtProt	NX_Q53H12
Antibodypedia	AGK antibodies

PROTEIN BROWSER

AGK-001	AGK-002	AGK-003	AGK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGK-001 ENSP00000347581 ENST00000355413	Q53H12 [Direct mapping] Acylglycerol kinase, mitochondrial A4D1U5 [Target identity:100%; Query identity:100%] Multiple substrate lipid kinase, isoform CRA_a; Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001727 [lipid kinase activity] GO:0001729 [ceramide kinase activity] GO:0004143 [diacylglycerol kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0046834 [lipid phosphorylation] GO:0047620 [acylglycerol kinase activity] Show all	422 aa 47.1 kDa	Yes	0
AGK-002 ENSP00000420776 ENST00000473247	E9PC15 [Direct mapping] Acylglycerol kinase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	394 aa 43.8 kDa	No	0
AGK-003 ENSP00000418789 ENST00000492693	Q53H12 [Direct mapping] Acylglycerol kinase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047620 [acylglycerol kinase activity] Show all	65 aa 7.6 kDa	Yes	0
AGK-201 ENSP00000487274 ENST00000629555	E9PG39 [Direct mapping] Acylglycerol kinase, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	244 aa 26.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.