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AGK

GENERAL INFORMATION

Gene name

 AGK

Gene description

 Acylglycerol kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA020959 , HPA053471
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA020959
HPA053471

GENE INFORMATION

Gene name

 AGK (HGNC Symbol)

Synonyms

 FLJ10842, MULK

Description

 Acylglycerol kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 141551189 - 141655244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006530 (version 83.38)

Entrez gene

 55750

UniProt

 Q53H12 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53H12

Antibodypedia

 AGK antibodies

PROTEIN BROWSER
AGK-001
AGK-002
AGK-003
AGK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGK-001
ENSP00000347581
ENST00000355413
Q53H12 [Direct mapping]
Acylglycerol kinase, mitochondrial
A4D1U5 [Target identity:100%; Query identity:100%]
Multiple substrate lipid kinase, isoform CRA_a; Uncharacterized protein
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001727 [lipid kinase activity]
GO:0001729 [ceramide kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046513 [ceramide biosynthetic process]
GO:0046834 [lipid phosphorylation]
GO:0047620 [acylglycerol kinase activity]
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 422 aa
47.1 kDa 		Yes 0
AGK-002
ENSP00000420776
ENST00000473247
E9PC15 [Direct mapping]
Acylglycerol kinase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005739 [mitochondrion]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
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 394 aa
43.8 kDa 		No 0
AGK-003
ENSP00000418789
ENST00000492693
Q53H12 [Direct mapping]
Acylglycerol kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047620 [acylglycerol kinase activity]
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 65 aa
7.6 kDa 		Yes 0
AGK-201
ENSP00000487274
ENST00000629555
E9PG39 [Direct mapping]
Acylglycerol kinase, mitochondrial
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 244 aa
26.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.