Expression of TTC22 in cancer - Summary - The Human Protein Atlas

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TTC22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TTC22
Gene description	Tetratricopeptide repeat domain 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, CAPAN-2, HaCaT, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035072
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and liver cancer (unfavourable).
Breast cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035072

GENE INFORMATION
Gene name	TTC22 (HGNC Symbol)
Synonyms	FLJ20619
Description	Tetratricopeptide repeat domain 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	54779712 - 54801267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006555 (version 83.38)
Entrez gene	55001
UniProt	Q5TAA0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5TAA0
Antibodypedia	TTC22 antibodies

PROTEIN BROWSER

TTC22-001	TTC22-002	TTC22-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC22-001 ENSP00000360321 ENST00000371274	Q5TAA0 [Direct mapping] Tetratricopeptide repeat protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	372 aa 41.8 kDa	No	0
TTC22-002 ENSP00000360323 ENST00000371276	Q5TAA0 [Direct mapping] Tetratricopeptide repeat protein 22 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	569 aa 63.4 kDa	No	0
TTC22-003 ENSP00000390300 ENST00000448308	H0Y486 [Direct mapping] Tetratricopeptide repeat protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.