Tissue expression of IFRD1 - Summary - The Human Protein Atlas

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IFRD1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IFRD1
Gene description	Interferon-related developmental regulator 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA024122
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	IFRD1 (HGNC Symbol)
Synonyms	PC4, TIS7
Description	Interferon-related developmental regulator 1 (HGNC Symbol)
Entrez gene summary	This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	112422968 - 112481017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006652 (version 83.38)
Entrez gene	3475
UniProt	O00458 (UniProt - Evidence at protein level)
neXtProt	NX_O00458
Antibodypedia	IFRD1 antibodies

PROTEIN BROWSER

IFRD1-001	IFRD1-002	IFRD1-003	IFRD1-005	IFRD1-006	IFRD1-007	IFRD1-008	IFRD1-009	IFRD1-011	IFRD1-013	IFRD1-014	IFRD1-201	IFRD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFRD1-001 ENSP00000005558 ENST00000005558	O00458 [Direct mapping] Interferon-related developmental regulator 1 A4D0U1 [Target identity:100%; Query identity:100%] Interferon-related developmental regulator 1; Interferon-related developmental regulator 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	451 aa 50.3 kDa	No	1
IFRD1-002 ENSP00000384477 ENST00000403825	O00458 [Direct mapping] Interferon-related developmental regulator 1 A4D0U1 [Target identity:100%; Query identity:100%] Interferon-related developmental regulator 1; Interferon-related developmental regulator 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007518 [myoblast fate determination] GO:0014706 [striated muscle tissue development] GO:0030517 [negative regulation of axon extension] GO:0042692 [muscle cell differentiation] GO:0043403 [skeletal muscle tissue regeneration] GO:0048671 [negative regulation of collateral sprouting] Show all	451 aa 50.3 kDa	No	1
IFRD1-003 ENSP00000397314 ENST00000429071	C9JA65 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 15.9 kDa	No	0
IFRD1-005 ENSP00000397592 ENST00000443101	C9J7U6 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.4 kDa	No	0
IFRD1-006 ENSP00000402453 ENST00000445335	C9JLG5 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.2 kDa	No	0
IFRD1-007 ENSP00000413893 ENST00000417662	C9JK78 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 1.9 kDa	No	0
IFRD1-008 ENSP00000437250 ENST00000476927	E9PMY4 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.3 kDa	No	0
IFRD1-009 ENSP00000402177 ENST00000440625	C9JNM6 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.9 kDa	No	0
IFRD1-011 ENSP00000403203 ENST00000421296	C9JFH1 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.4 kDa	No	0
IFRD1-013 ENSP00000435635 ENST00000462155	H0YEE3 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.4 kDa	No	0
IFRD1-014 ENSP00000391379 ENST00000432734	C9J311 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 2.9 kDa	No	0
IFRD1-201 ENSP00000439188 ENST00000535603	O00458 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	401 aa 45.3 kDa	No	1
IFRD1-202 ENSP00000483255 ENST00000621379	O00458 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	401 aa 45.3 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.