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Several cases of malignant melanomas, endometrial and ovarian cancers along with a few breast, liver, pancreatic and lung cancers showed weak to moderate cytoplasmic positivity. Strong staining was observed in a few malignant melanomas. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
ADIPOR2 (HGNC Symbol)
Synonyms
ACDCR2, PAQR2
Description
Adiponectin receptor 2 (HGNC Symbol)
Entrez gene summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]