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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADIPOR2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADIPOR2

Gene description

Adiponectin receptor 2

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA043737
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043737

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of malignant melanomas, endometrial and ovarian cancers along with a few breast, liver, pancreatic and lung cancers showed weak to moderate cytoplasmic positivity. Strong staining was observed in a few malignant melanomas. Remaining malignant cells were in general negative.

GENE INFORMATION

Gene name

ADIPOR2 (HGNC Symbol)

Synonyms

ACDCR2, PAQR2

Description

Adiponectin receptor 2 (HGNC Symbol)

Entrez gene summary

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Chromosome

12

Cytoband

p13.33

Chromosome location (bp)

1688574 - 1788678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000006831 (version 83.38)

Entrez gene

79602

UniProt

Q86V24 (UniProt - Evidence at protein level)

neXtProt

NX_Q86V24

Antibodypedia

ADIPOR2 antibodies

PROTEIN BROWSER

ADIPOR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADIPOR2-001
ENSP00000349616
ENST00000357103
Q86V24 [Direct mapping]
Adiponectin receptor protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007584 [response to nutrient]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0019395 [fatty acid oxidation]
GO:0030308 [negative regulation of cell growth]
GO:0031226 [intrinsic component of plasma membrane]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0042562 [hormone binding]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0046326 [positive regulation of glucose import]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0055100 [adiponectin binding]
GO:0061042 [vascular wound healing]
GO:0097003 [adipokinetic hormone receptor activity]
Show all
386 aa
43.9 kDa
No 7

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