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ADIPOR2

GENERAL INFORMATION

Gene name

 ADIPOR2

Gene description

 Adiponectin receptor 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043737
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ADIPOR2 (HGNC Symbol)

Synonyms

 ACDCR2, PAQR2

Description

 Adiponectin receptor 2 (HGNC Symbol)

Entrez gene summary

 The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 1688574 - 1788678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006831 (version 83.38)

Entrez gene

 79602

UniProt

 Q86V24 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86V24

Antibodypedia

 ADIPOR2 antibodies

PROTEIN BROWSER
ADIPOR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADIPOR2-001
ENSP00000349616
ENST00000357103
Q86V24 [Direct mapping]
Adiponectin receptor protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007584 [response to nutrient]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0019395 [fatty acid oxidation]
GO:0030308 [negative regulation of cell growth]
GO:0031226 [intrinsic component of plasma membrane]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0042562 [hormone binding]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0046326 [positive regulation of glucose import]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0055100 [adiponectin binding]
GO:0061042 [vascular wound healing]
GO:0097003 [adipokinetic hormone receptor activity]
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 386 aa
43.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.