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The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007498 [mesoderm development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007498 [mesoderm development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007498 [mesoderm development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007498 [mesoderm development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0045087 [innate immune response]