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MATK

GENERAL INFORMATION

Gene name

 MATK

Gene description

 Megakaryocyte-associated tyrosine kinase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HL-60, K-562, NB-4, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, high expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004847
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA004847

GENE INFORMATION

Gene name

 MATK (HGNC Symbol)

Synonyms

 CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101

Description

 Megakaryocyte-associated tyrosine kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 3777970 - 3802129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007264 (version 83.38)

Entrez gene

 4145

UniProt

 P42679 (UniProt - Evidence at protein level)

neXtProt

 NX_P42679

Antibodypedia

 MATK antibodies

PROTEIN BROWSER
«
MATK-001
MATK-002
MATK-003
MATK-004
MATK-005
MATK-006
MATK-007
MATK-008
MATK-009
MATK-010
MATK-011
MATK-201
MATK-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MATK-001
ENSP00000378485
ENST00000395045
P42679 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 508 aa
56.8 kDa 		No 0
MATK-002
ENSP00000378481
ENST00000395040
P42679 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 466 aa
51.9 kDa 		No 0
MATK-003
ENSP00000308734
ENST00000310132
P42679 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
F1T0G6 [Target identity:100%; Query identity:100%]
Non-specific protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 507 aa
56.5 kDa 		No 0
MATK-004
ENSP00000468030
ENST00000585778
K7EQY5 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 506 aa
56.3 kDa 		No 0
MATK-005
ENSP00000467992
ENST00000590849
K7EQV3 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 84 aa
9.5 kDa 		No 0
MATK-006
ENSP00000467006
ENST00000590028
K7ENL8 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 174 aa
19.6 kDa 		No 0
MATK-007
ENSP00000465556
ENST00000591059
K7EKC4 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 13 aa
1.4 kDa 		No 0
MATK-008
ENSP00000468465
ENST00000587180
K7ERY4 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 131 aa
14.8 kDa 		No 0
MATK-009
ENSP00000465761
ENST00000588983
K7EKS5 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 237 aa
26.2 kDa 		No 0
MATK-010
ENSP00000468576
ENST00000590493
K7ES68 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 267 aa
29.8 kDa 		No 0
MATK-011
ENSP00000467472
ENST00000590980
K7EPP2 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 38 aa
4.3 kDa 		No 0
MATK-201
ENSP00000478847
ENST00000612526
A0A087WUR1 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 527 aa
58.6 kDa 		No 0
MATK-202
ENSP00000483213
ENST00000619596
P42679 [Direct mapping]
Megakaryocyte-associated tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 508 aa
56.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.