Cell atlas - DLEC1 - The Human Protein Atlas

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DLEC1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	DLEC1
Gene description	Deleted in lung and esophageal cancer 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA019077
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019077	A-431	Cytosol
	HPA019077	U-2 OS	Cytosol
	HPA019077	U-251 MG	Cytosol

GENE INFORMATION
Gene name	DLEC1 (HGNC Symbol)
Synonyms	CFAP81, DLC1
Description	Deleted in lung and esophageal cancer 1 (HGNC Symbol)
Entrez gene summary	This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38039205 - 38124025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008226 (version 83.38)
Entrez gene	9940
UniProt	Q9Y238 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y238
Antibodypedia	DLEC1 antibodies

PROTEIN BROWSER

DLEC1-001	DLEC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLEC1-001 ENSP00000308597 ENST00000308059	Q9Y238 [Direct mapping] Deleted in lung and esophageal cancer protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] Show all	1755 aa 195.7 kDa	No	0
DLEC1-201 ENSP00000315914 ENST00000346219	Q9Y238 [Direct mapping] Deleted in lung and esophageal cancer protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] Show all	1778 aa 197.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.