Expression of DLEC1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DLEC1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DLEC1
Gene description	Deleted in lung and esophageal cancer 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in ciliated cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA019077
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019077

GENE INFORMATION
Gene name	DLEC1 (HGNC Symbol)
Synonyms	CFAP81, DLC1
Description	Deleted in lung and esophageal cancer 1 (HGNC Symbol)
Entrez gene summary	This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38039205 - 38124025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008226 (version 83.38)
Entrez gene	9940
UniProt	Q9Y238 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y238
Antibodypedia	DLEC1 antibodies

PROTEIN BROWSER

DLEC1-001	DLEC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLEC1-001 ENSP00000308597 ENST00000308059	Q9Y238 [Direct mapping] Deleted in lung and esophageal cancer protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] Show all	1755 aa 195.7 kDa	No	0
DLEC1-201 ENSP00000315914 ENST00000346219	Q9Y238 [Direct mapping] Deleted in lung and esophageal cancer protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] Show all	1778 aa 197.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.