Cell atlas - CELSR3 - The Human Protein Atlas

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CELSR3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CELSR3
Gene description	Cadherin, EGF LAG seven-pass G-type receptor 3
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CELSR3 (HGNC Symbol)
Synonyms	ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2
Description	Cadherin, EGF LAG seven-pass G-type receptor 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48636469 - 48662915
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008300 (version 83.38)
Entrez gene	1951
UniProt	Q9NYQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYQ7
Antibodypedia	CELSR3 antibodies

PROTEIN BROWSER

CELSR3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELSR3-001 ENSP00000164024 ENST00000164024	Q9NYQ7 [Direct mapping] Cadherin EGF LAG seven-pass G-type receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0001932 [regulation of protein phosphorylation] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007413 [axonal fasciculation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032880 [regulation of protein localization] GO:0042384 [cilium assembly] Show all	3312 aa 358.2 kDa	Yes	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.