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CELSR3

GENERAL INFORMATION

Gene name

 CELSR3

Gene description

 Cadherin, EGF LAG seven-pass G-type receptor 3

Protein class

 G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in cerebellum, testis and adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. GTEx data supports antibody staining in cerebellum.

Reliability score

 Approved based on 1 antibody.
HPA062866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA062866

GENE INFORMATION

Gene name

 CELSR3 (HGNC Symbol)

Synonyms

 ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2

Description

 Cadherin, EGF LAG seven-pass G-type receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48636469 - 48662915

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000008300 (version 83.38)

Entrez gene

 1951

UniProt

 Q9NYQ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYQ7

Antibodypedia

 CELSR3 antibodies

PROTEIN BROWSER
CELSR3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CELSR3-001
ENSP00000164024
ENST00000164024
Q9NYQ7 [Direct mapping]
Cadherin EGF LAG seven-pass G-type receptor 3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0001932 [regulation of protein phosphorylation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007413 [axonal fasciculation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032880 [regulation of protein localization]
GO:0042384 [cilium assembly]
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 3312 aa
358.2 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.