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NFIX

GENERAL INFORMATION

Gene name

 NFIX

Gene description

 Nuclear factor I/X (CCAAT-binding transcription factor)

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-138 MG, U-2197)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007533
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and liver cancer (favourable).
Lung cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA007533

GENE INFORMATION

Gene name

 NFIX (HGNC Symbol)

Synonyms

 NF1A

Description

 Nuclear factor I/X (CCAAT-binding transcription factor) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12995608 - 13098796

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000008441 (version 83.38)

Entrez gene

 4784

UniProt

 Q14938 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14938

Antibodypedia

 NFIX antibodies

PROTEIN BROWSER
«
NFIX-001
NFIX-002
NFIX-003
NFIX-004
NFIX-006
NFIX-007
NFIX-008
NFIX-010
NFIX-011
NFIX-013
NFIX-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFIX-001
ENSP00000380781
ENST00000397661
Q14938 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021549 [cerebellum development]
GO:0021680 [cerebellar Purkinje cell layer development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048708 [astrocyte differentiation]
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 441 aa
48.9 kDa 		No 0
NFIX-002
ENSP00000466389
ENST00000587760
Q14938 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 433 aa
47.9 kDa 		No 0
NFIX-003
ENSP00000353219
ENST00000360105
C9JWJ8 [Direct mapping]
Nuclear factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
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 403 aa
44.7 kDa 		No 0
NFIX-004
ENSP00000466735
ENST00000588228
K7EN08 [Direct mapping]
Nuclear factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 455 aa
49.2 kDa 		No 0
NFIX-006
ENSP00000468794
ENST00000585575
Q14938 [Direct mapping]
Nuclear factor 1 X-type
D2DXM9 [Target identity:100%; Query identity:100%]
Nuclear factor 1
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 494 aa
54.1 kDa 		No 0
NFIX-007
ENSP00000467785
ENST00000587260
Q14938 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 440 aa
48.7 kDa 		No 0
NFIX-008
ENSP00000465616
ENST00000590027
K7EKH0 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 128 aa
14.7 kDa 		No 0
NFIX-010
ENSP00000465094
ENST00000591028
K7EJB0 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 183 aa
21.2 kDa 		No 0
NFIX-011
ENSP00000468707
ENST00000586873
K7ESG9 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 125 aa
14.4 kDa 		No 0
NFIX-013
ENSP00000467512
ENST00000592199
Q14938 [Direct mapping]
Nuclear factor 1 X-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 502 aa
55.1 kDa 		No 0
NFIX-201
ENSP00000351354
ENST00000358552
C9JWJ8 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 403 aa
44.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.