Expression of CD9 in cancer - Summary - The Human Protein Atlas

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CD9

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD9
Gene description	CD9 molecule
Protein class	Cancer-related genes CD markers Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB002490
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), thyroid cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002490

GENE INFORMATION
Gene name	CD9 (HGNC Symbol)
Synonyms	BA2, MIC3, MRP-1, P24, TSPAN29
Description	CD9 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6199715 - 6238271
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010278 (version 83.38)
Entrez gene	928
UniProt	P21926 (UniProt - Evidence at protein level)
neXtProt	NX_P21926
Antibodypedia	CD9 antibodies

PROTEIN BROWSER

CD9-001	CD9-003	CD9-004	CD9-010	CD9-011	CD9-201	CD9-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD9-001 ENSP00000009180 ENST00000009180	P21926 [Direct mapping] CD9 antigen Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007338 [single fertilization] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0030666 [endocytic vesicle membrane] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0030913 [paranodal junction assembly] GO:0031092 [platelet alpha granule membrane] GO:0032504 [multicellular organism reproduction] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	228 aa 25.4 kDa	No	4
CD9-003 ENSP00000371955 ENST00000382515	A6NNI4 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	159 aa 17.8 kDa	Yes	2
CD9-004 ENSP00000371958 ENST00000382518	P21926 [Direct mapping] CD9 antigen Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007338 [single fertilization] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007420 [brain development] GO:0007596 [blood coagulation] GO:0008285 [negative regulation of cell proliferation] GO:0009414 [response to water deprivation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030168 [platelet activation] GO:0030666 [endocytic vesicle membrane] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0030913 [paranodal junction assembly] GO:0031092 [platelet alpha granule membrane] GO:0032504 [multicellular organism reproduction] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	228 aa 25.4 kDa	No	4
CD9-010 ENSP00000371959 ENST00000382519	G8JLH6 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	228 aa 25.4 kDa	No	3
CD9-011 ENSP00000440985 ENST00000536586	F5GXT1 [Direct mapping] CD9 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	142 aa 16 kDa	No	3
CD9-201 ENSP00000478288 ENST00000610354	A0A087WU13 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	182 aa 20.8 kDa	No	3
CD9-202 ENSP00000482643 ENST00000617871	A0A087WZG3 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	181 aa 20.6 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
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