Expression of NCAPD2 in cancer - Summary

GENERAL INFORMATION
Gene name	NCAPD2
Gene description	Non-SMC condensin I complex, subunit D2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression with additional cytoplasmic expression in several tissues, most abundant in reaction center cells of lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA036947 , HPA037363 , CAB012423
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036947	HPA037363	CAB012423

GENE INFORMATION
Gene name	NCAPD2 (HGNC Symbol)
Synonyms	CAP-D2, CNAP1, hCAP-D2, KIAA0159
Description	Non-SMC condensin I complex, subunit D2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6493356 - 6531955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010292 (version 83.38)
Entrez gene	9918
UniProt	Q15021 (UniProt - Evidence at protein level)
neXtProt	NX_Q15021
Antibodypedia	NCAPD2 antibodies

PROTEIN BROWSER

NCAPD2-001	NCAPD2-002	NCAPD2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPD2-001 ENSP00000325017 ENST00000315579	Q15021 [Direct mapping] Condensin complex subunit 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000278 [mitotic cell cycle] GO:0000779 [condensed chromosome, centromeric region] GO:0000793 [condensed chromosome] GO:0000796 [condensin complex] GO:0000797 [condensin core heterodimer] GO:0000799 [nuclear condensin complex] GO:0003682 [chromatin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007076 [mitotic chromosome condensation] GO:0010032 [meiotic chromosome condensation] GO:0016020 [membrane] GO:0030261 [chromosome condensation] GO:0042393 [histone binding] GO:0051301 [cell division] GO:0051304 [chromosome separation] Show all	1401 aa 157.2 kDa	No	0
NCAPD2-002 ENSP00000371895 ENST00000382457	E7EN77 [Direct mapping] Condensin complex subunit 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007076 [mitotic chromosome condensation] GO:0030261 [chromosome condensation] Show all	919 aa 102.6 kDa	No	0
NCAPD2-005 ENSP00000444377 ENST00000539714	F5GZK7 [Direct mapping] Condensin complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007076 [mitotic chromosome condensation] Show all	118 aa 13.3 kDa	No	0