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BTK

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GENERAL INFORMATION

Gene name

 BTK

Gene description

 Bruton agammaglobulinemia tyrosine kinase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (HMC-1, HEL)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA001198
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001198 A-431 Vesicles
HPA001198 U-2 OS Vesicles
HPA001198 U-251 MG Vesicles

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000031264 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA001198 NIH 3T3 No staining

GENE INFORMATION

Gene name

 BTK (HGNC Symbol)

Synonyms

 AGMX1, ATK, IMD1, PSCTK1, XLA

Description

 Bruton agammaglobulinemia tyrosine kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 101349447 - 101390796

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010671 (version 83.38)

Entrez gene

 695

UniProt

 Q06187 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06187

Antibodypedia

 BTK antibodies

PROTEIN BROWSER
BTK-006
BTK-201
BTK-202
BTK-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BTK-006
ENSP00000308176
ENST00000308731
Q06187 [Direct mapping]
Tyrosine-protein kinase BTK
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002721 [regulation of B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042113 [B cell activation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045579 [positive regulation of B cell differentiation]
GO:0046872 [metal ion binding]
GO:0050853 [B cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0097190 [apoptotic signaling pathway]
Show all
 659 aa
76.3 kDa 		No 0
BTK-201
ENSP00000361971
ENST00000372880
Q5JY90 [Direct mapping]
Bruton agammaglobulinemia tyrosine kinase, isoform CRA_b; Tyrosine-protein kinase BTK; cDNA FLJ32543 fis, clone SMINT2000538, highly similar to Tyrosine-protein kinase BTK (EC 2.7.10.2)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 483 aa
55.9 kDa 		No 0
BTK-202
ENSP00000479125
ENST00000618050
U3NG26 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
Show all
 568 aa
65.5 kDa 		No 0
BTK-203
ENSP00000483570
ENST00000621635
Q06187 [Direct mapping]
Tyrosine-protein kinase BTK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001818 [negative regulation of cytokine production]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002721 [regulation of B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007498 [mesoderm development]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042113 [B cell activation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045579 [positive regulation of B cell differentiation]
GO:0046872 [metal ion binding]
GO:0048469 [cell maturation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0097190 [apoptotic signaling pathway]
Show all
 693 aa
79.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.