Cell atlas - FMO1 - The Human Protein Atlas

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FMO1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FMO1
Gene description	Flavin containing monooxygenase 1
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FMO1
Synonyms
Description	Flavin containing monooxygenase 1 (HGNC Symbol)
Entrez gene summary	Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	1
Cytoband	q24.3
Chromosome location (bp)	171248471 - 171285978
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010932 (version 83.38)
Entrez gene	2326
UniProt	Q01740 (UniProt - Evidence at transcript level)
neXtProt	NX_Q01740
Antibodypedia	FMO1 antibodies

PROTEIN BROWSER

FMO1-001	FMO1-003	FMO1-006	FMO1-201	FMO1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FMO1-001 ENSP00000356724 ENST00000367750	Q01740 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 1 A0A024R934 [Target identity:100%; Query identity:100%] Dimethylaniline monooxygenase [N-oxide-forming] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006082 [organic acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009404 [toxin metabolic process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0070995 [NADPH oxidation] Show all	532 aa 60.3 kDa	Yes	1
FMO1-003 ENSP00000346901 ENST00000354841	Q01740 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 1 A0A024R934 [Target identity:100%; Query identity:100%] Dimethylaniline monooxygenase [N-oxide-forming] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006082 [organic acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009404 [toxin metabolic process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0070995 [NADPH oxidation] Show all	532 aa 60.3 kDa	Yes	1
FMO1-006 ENSP00000406982 ENST00000433267	Q5QPT3 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	208 aa 23.3 kDa	Yes	0
FMO1-201 ENSP00000385543 ENST00000402921	Q01740 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006082 [organic acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009404 [toxin metabolic process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0070995 [NADPH oxidation] Show all	469 aa 52.8 kDa	Yes	1
FMO1-202 ENSP00000481732 ENST00000617670	Q01740 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 1 A0A024R934 [Target identity:100%; Query identity:100%] Dimethylaniline monooxygenase [N-oxide-forming] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006082 [organic acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006970 [response to osmotic stress] GO:0009404 [toxin metabolic process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0032496 [response to lipopolysaccharide] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0070995 [NADPH oxidation] Show all	532 aa 60.3 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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