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FMO1

GENERAL INFORMATION

Gene name

 FMO1

Gene description

 Flavin containing monooxygenase 1

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enhanced (kidney)
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, highest in liver, kidney and pancreas. Additional expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA023680
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 FMO1

Synonyms

Description

 Flavin containing monooxygenase 1 (HGNC Symbol)

Entrez gene summary

 Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 1

Cytoband

 q24.3

Chromosome location (bp)

 171248471 - 171285978

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010932 (version 83.38)

Entrez gene

 2326

UniProt

 Q01740 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q01740

Antibodypedia

 FMO1 antibodies

PROTEIN BROWSER
FMO1-001
FMO1-003
FMO1-006
FMO1-201
FMO1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FMO1-001
ENSP00000356724
ENST00000367750
Q01740 [Direct mapping]
Dimethylaniline monooxygenase [N-oxide-forming] 1
A0A024R934 [Target identity:100%; Query identity:100%]
Dimethylaniline monooxygenase [N-oxide-forming]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0004499 [N,N-dimethylaniline monooxygenase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006082 [organic acid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009404 [toxin metabolic process]
GO:0016021 [integral component of membrane]
GO:0017144 [drug metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070995 [NADPH oxidation]
Show all
 532 aa
60.3 kDa 		Yes 1
FMO1-003
ENSP00000346901
ENST00000354841
Q01740 [Direct mapping]
Dimethylaniline monooxygenase [N-oxide-forming] 1
A0A024R934 [Target identity:100%; Query identity:100%]
Dimethylaniline monooxygenase [N-oxide-forming]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0004499 [N,N-dimethylaniline monooxygenase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006082 [organic acid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009404 [toxin metabolic process]
GO:0016021 [integral component of membrane]
GO:0017144 [drug metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070995 [NADPH oxidation]
Show all
 532 aa
60.3 kDa 		Yes 1
FMO1-006
ENSP00000406982
ENST00000433267
Q5QPT3 [Direct mapping]
Dimethylaniline monooxygenase [N-oxide-forming] 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004499 [N,N-dimethylaniline monooxygenase activity]
GO:0017144 [drug metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 208 aa
23.3 kDa 		Yes 0
FMO1-201
ENSP00000385543
ENST00000402921
Q01740 [Direct mapping]
Dimethylaniline monooxygenase [N-oxide-forming] 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0004499 [N,N-dimethylaniline monooxygenase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006082 [organic acid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009404 [toxin metabolic process]
GO:0016021 [integral component of membrane]
GO:0017144 [drug metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070995 [NADPH oxidation]
Show all
 469 aa
52.8 kDa 		Yes 1
FMO1-202
ENSP00000481732
ENST00000617670
Q01740 [Direct mapping]
Dimethylaniline monooxygenase [N-oxide-forming] 1
A0A024R934 [Target identity:100%; Query identity:100%]
Dimethylaniline monooxygenase [N-oxide-forming]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0004499 [N,N-dimethylaniline monooxygenase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006082 [organic acid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006970 [response to osmotic stress]
GO:0009404 [toxin metabolic process]
GO:0016021 [integral component of membrane]
GO:0017144 [drug metabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070995 [NADPH oxidation]
Show all
 532 aa
60.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.