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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABHD5
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABHD5

Gene description

Abhydrolase domain containing 5

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including adipose tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA035851 , HPA035852 , CAB020685
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA035851
HPA035852
CAB020685

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most testicular and colorectal cancers along with several melanomas, breast, ovarian, endometrial, urothelial, stomach and pancreatic cancers displayed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were essentially negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed weak to moderate cytoplasmic positivity and nuclear staining. Several cases of testicular, gastric and liver cancers were strongly stained. Several renal cancers were negative.

GENE INFORMATION

Gene name

ABHD5 (HGNC Symbol)

Synonyms

CGI-58, NCIE2

Description

Abhydrolase domain containing 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.33

Chromosome location (bp)

43690113 - 43734371

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000011198 (version 83.38)

Entrez gene

51099

UniProt

Q8WTS1 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WTS1

Antibodypedia

ABHD5 antibodies

PROTEIN BROWSER

ABHD5-001
ABHD5-003
ABHD5-005
ABHD5-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABHD5-001
ENSP00000390849
ENST00000458276
Q8WTS1 [Direct mapping]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
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Enzymes
   ENZYME proteins
   Transferases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0019433 [triglyceride catabolic process]
GO:0030154 [cell differentiation]
GO:0042171 [lysophosphatidic acid acyltransferase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0055088 [lipid homeostasis]
Show all
349 aa
39.1 kDa
No 0
ABHD5-003
ENSP00000412014
ENST00000454293
C9J1D1 [Direct mapping]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
45 aa
5.1 kDa
No 0
ABHD5-005
ENSP00000391582
ENST00000456453
C9JBM3 [Direct mapping]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
Show all
127 aa
14.2 kDa
No 0
ABHD5-006
ENSP00000392159
ENST00000413300
H7BZY9 [Direct mapping]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
155 aa
18.1 kDa
No 0

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