Tissue expression of ABHD5 - Summary - The Human Protein Atlas

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ABHD5

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABHD5
Gene description	Abhydrolase domain containing 5
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including adipose tissue.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA035851 , HPA035852 , CAB020685
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

N/A

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ABHD5 (HGNC Symbol)
Synonyms	CGI-58, NCIE2
Description	Abhydrolase domain containing 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.33
Chromosome location (bp)	43690113 - 43734371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011198 (version 83.38)
Entrez gene	51099
UniProt	Q8WTS1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WTS1
Antibodypedia	ABHD5 antibodies

PROTEIN BROWSER

ABHD5-001	ABHD5-003	ABHD5-005	ABHD5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD5-001 ENSP00000390849 ENST00000458276	Q8WTS1 [Direct mapping] 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Show all	Enzymes ENZYME proteins Transferases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006631 [fatty acid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0010898 [positive regulation of triglyceride catabolic process] GO:0019433 [triglyceride catabolic process] GO:0030154 [cell differentiation] GO:0042171 [lysophosphatidic acid acyltransferase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0050996 [positive regulation of lipid catabolic process] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0052689 [carboxylic ester hydrolase activity] GO:0055088 [lipid homeostasis] Show all	349 aa 39.1 kDa	No	0
ABHD5-003 ENSP00000412014 ENST00000454293	C9J1D1 [Direct mapping] 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		45 aa 5.1 kDa	No	0
ABHD5-005 ENSP00000391582 ENST00000456453	C9JBM3 [Direct mapping] 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	127 aa 14.2 kDa	No	0
ABHD5-006 ENSP00000392159 ENST00000413300	H7BZY9 [Direct mapping] 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 18.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.