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ANOS1

GENERAL INFORMATION

Gene name

 ANOS1

Gene description

 Anosmin 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (NTERA-2, U-2 OS)
HPA (normal tissue):Group enriched (cerebral cortex, lung, parathyroid gland, thyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ANOS1 (HGNC Symbol)

Synonyms

 ADMLX, KAL, KAL1, KALIG-1, WFDC19

Description

 Anosmin 1 (HGNC Symbol)

Entrez gene summary

 Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.31

Chromosome location (bp)

 8528874 - 8732187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011201 (version 83.38)

Entrez gene

 3730

UniProt

 P23352 (UniProt - Evidence at protein level)

neXtProt

 NX_P23352

Antibodypedia

 ANOS1 antibodies

PROTEIN BROWSER
ANOS1-001
ANOS1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANOS1-001
ENSP00000262648
ENST00000262648
P23352 [Direct mapping]
Anosmin-1
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030414 [peptidase inhibitor activity]
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 680 aa
76.1 kDa 		Yes 0
ANOS1-201
ENSP00000478734
ENST00000619786
A0A087WUK9 [Direct mapping]
Protein ANOS1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0010466 [negative regulation of peptidase activity]
GO:0030414 [peptidase inhibitor activity]
Show all
 679 aa
76.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.