Tissue expression of ANOS1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ANOS1
Gene description	Anosmin 1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, lung, parathyroid gland, thyroid gland)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, lung, parathyroid gland, thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	ANOS1 (HGNC Symbol)
Synonyms	ADMLX, KAL, KAL1, KALIG-1, WFDC19
Description	Anosmin 1 (HGNC Symbol)
Entrez gene summary	Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.31
Chromosome location (bp)	8528874 - 8732187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011201 (version 83.38)
Entrez gene	3730
UniProt	P23352 (UniProt - Evidence at protein level)
neXtProt	NX_P23352
Antibodypedia	ANOS1 antibodies

PROTEIN BROWSER

ANOS1-001	ANOS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANOS1-001 ENSP00000262648 ENST00000262648	P23352 [Direct mapping] Anosmin-1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	680 aa 76.1 kDa	Yes	0
ANOS1-201 ENSP00000478734 ENST00000619786	A0A087WUK9 [Direct mapping] Protein ANOS1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010466 [negative regulation of peptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	679 aa 76.2 kDa	Yes	0