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ELOVL5

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GENERAL INFORMATION

Gene name

 ELOVL5

Gene description

 ELOVL fatty acid elongase 5

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the endoplasmic reticulum.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (validated)

Mouse

 Localized to the Endoplasmic reticulum in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB017042 , HPA047752 , HPA054197
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017042 A-431 No staining    
CAB017042 U-2 OS Nuclear speckles
Endoplasmic reticulum
CAB017042 U-251 MG Endoplasmic reticulum
HPA047752 A-431 Endoplasmic reticulum
HPA047752 U-2 OS Endoplasmic reticulum
HPA047752 U-251 MG Endoplasmic reticulum
HPA054197 A-431 No staining    
HPA054197 U-2 OS No staining    
HPA054197 U-251 MG Endoplasmic reticulum

MOUSE CELLS

Main location

 Endoplasmic reticulum

Mouse gene

 ENSMUSG00000032349 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA047752 NIH 3T3 Endoplasmic reticulum

GENE INFORMATION

Gene name

 ELOVL5 (HGNC Symbol)

Synonyms

 dJ483K16.1, HELO1, SCA38

Description

 ELOVL fatty acid elongase 5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 53267398 - 53349179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012660 (version 83.38)

Entrez gene

 60481

UniProt

 Q9NYP7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYP7

Antibodypedia

 ELOVL5 antibodies

PROTEIN BROWSER
ELOVL5-001
ELOVL5-002
ELOVL5-201
ELOVL5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELOVL5-001
ENSP00000306640
ENST00000304434
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
A0A024RD35 [Target identity:100%; Query identity:100%]
Elongation of very long chain fatty acids protein
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
Show all
 299 aa
35.3 kDa 		No 7
ELOVL5-002
ENSP00000359951
ENST00000370913
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
Show all
 88 aa
9.6 kDa 		No 0
ELOVL5-201
ENSP00000359956
ENST00000370918
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
Show all
 326 aa
38.4 kDa 		No 7
ELOVL5-202
ENSP00000440728
ENST00000542638
A0A0A0MTI6 [Direct mapping]
Elongation of very long chain fatty acids protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006633 [fatty acid biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
Show all
 262 aa
30.7 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.