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ELOVL5

GENERAL INFORMATION

Gene name

 ELOVL5

Gene description

 ELOVL fatty acid elongase 5

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues. Highly expressed in mammary, adrenal and sebaceous glands, and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA047752 , CAB017042
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ELOVL5 (HGNC Symbol)

Synonyms

 dJ483K16.1, HELO1, SCA38

Description

 ELOVL fatty acid elongase 5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 53267398 - 53349179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012660 (version 83.38)

Entrez gene

 60481

UniProt

 Q9NYP7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYP7

Antibodypedia

 ELOVL5 antibodies

PROTEIN BROWSER
ELOVL5-001
ELOVL5-002
ELOVL5-201
ELOVL5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELOVL5-001
ENSP00000306640
ENST00000304434
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
A0A024RD35 [Target identity:100%; Query identity:100%]
Elongation of very long chain fatty acids protein
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
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 299 aa
35.3 kDa 		No 7
ELOVL5-002
ENSP00000359951
ENST00000370913
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
Show all
 88 aa
9.6 kDa 		No 0
ELOVL5-201
ENSP00000359956
ENST00000370918
Q9NYP7 [Direct mapping]
Elongation of very long chain fatty acids protein 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030425 [dendrite]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097447 [dendritic tree]
Show all
 326 aa
38.4 kDa 		No 7
ELOVL5-202
ENSP00000440728
ENST00000542638
A0A0A0MTI6 [Direct mapping]
Elongation of very long chain fatty acids protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006633 [fatty acid biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
Show all
 262 aa
30.7 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.