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MAP4K5

GENERAL INFORMATION

Gene name

 MAP4K5

Gene description

 Mitogen-activated protein kinase kinase kinase kinase 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of tissues, mainly smooth muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA036696
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP4K5 (HGNC Symbol)

Synonyms

 GCKR, KHS, KHS1

Description

 Mitogen-activated protein kinase kinase kinase kinase 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 50418501 - 50561126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012983 (version 83.38)

Entrez gene

 11183

UniProt

neXtProt

Antibodypedia

 MAP4K5 antibodies

PROTEIN BROWSER
MAP4K5-001
MAP4K5-004
MAP4K5-006
MAP4K5-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP4K5-001
ENSP00000013125
ENST00000013125
A0A0A0MQR1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 846 aa
95 kDa 		No 0
MAP4K5-004
ENSP00000451452
ENST00000554273
G3V3V7 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 56 aa
6.2 kDa 		No 0
MAP4K5-006
ENSP00000451980
ENST00000557390
G3V4T8 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 137 aa
15.5 kDa 		No 0
MAP4K5-008
ENSP00000452289
ENST00000555216
G3V5C6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 108 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.